Catch any Melbourne train that goes through the City Loop and hop off at Southern Cross station. 750 Collins Street is only a 300m walk from there.

Trams #11 and #48 from the north and east of the city stop on the doorstep of 750 Collins Street.

There’s a bus stop directly in front of the building that services routes from the west of the city: 232 (Altona to City), 235 (Fishermans Bend via Williamstown Rd to City) and 237 (Fishermans Bend via Lorimer Street to City).